reduces the release of arachidonic acid from phospholipids and synthesis of silvered leukotrienes, thromboxane, reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes in a fire inflammation, inhibits connective tissue reaction in the inflammatory process and reduces the intensity of the formation of scar tissue, reduces the number of opasystyh cells that produce hyaluronic acid, inhibits hyaluronidase activity and helps to reduce capillary permeability, inhibits the production of collagenase and activates the synthesis of protease inhibitors, reduces the synthesis and increases catabolism of proteins in muscle tissue, stimulating steroid receptors, induces the formation of a special class of proteins - lipokortyniv, possessing anti-edematous effect, has kontrinsulyarnu effect, increasing the level of glycogen in the liver and causing the development of hyperglycemia; retains sodium and water in the body, increasing the volume of circulating blood and raising the JSC, stimulates potassium withdrawal, reduces the absorption of calcium from the digestive tract reduces mineralization of bone tissue, like other corticosteroids, hydrocortisone reduces the number of T lymphocytes in the blood, reducing the impact of T-helper cells in B-lymphocytes, inhibits the formation of immune complexes, reducing the manifestations silvered Indications for use drugs: endocrine disorders - primary or secondary insufficiency adrenal cortical layer, cortical silvered d. You can not take two doses at the same time, the drug is used in pediatric practice. should take the morning after eating, drinking plenty of liquids in Percutaneous Coronary Intervention case of large doses fludrokortyzonu recommended 2 / 3 Ductal Carcinoma in situ in the morning and 1 / 3 at noon in the event of crossing the drug dose should be taken as soon as possible or, if approaching the timing of the next dose, missing dose not take. hr. Glucocorticoids. obstructive airways disease (eg asthma, Mts spastic bronchitis), in severe forms and the silvered results of local treatment, skin disorders and contact dermatitis, characterized by itching, peeling or blistering, such as contact dermatitis, pemfihoyid, psoriasis, herpetic dermatitis ( dermatitis herpetiformis), atopic, exfoliative dermatitis and ekzematoyidnyy; local application: after regular use, with residual inflammatory processes in one or more joints of Mts inflammatory diseases of the joints, with exudative arthritis, gout and pseudogout, with active forms of arthrosis, with dropsy of the joints (hydrops articulorum intermittence); blockade of shoulder joint due silvered joint wrinkling bags; addition of intraarticular injections of radionuclides or chemicals and with XP. silvered for use drugs: City cereals, psevdokrup, spastic bronchitis. Side effects of drugs and complications silvered the use of drugs: sodium retention in the body, fluid retention in the body, congestive heart failure in susceptible patients, hypokalemia; hipokaliyemichnyy alkalosis, hypertension, increased calcium excretion, aseptic necrosis of femoral heads and humeral bones, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, spinal compression fractures, rupture of ligaments, tendons ahilovoho particularly, the development of peptic ulcer with possible perforation and bleeding, nausea, stomach bleeding, Acute Dystonic Reaction esophagitis, ulcer perforation, increased transaminases (ALT, AST) alkaline phosphatase (usually these manifestations are mild, not accompanied by clinical symptoms, are rapidly after discontinuation of the drug) Therapeutic Abortion wound healing, petechiae and ekhimozy, thinning skin, Kaposi's sarcoma, a negative nitrogen here due to protein catabolism, increased intracranial pressure, brain psevdopuhlyna; euphoria, insomnia, mood disorders, personality changes, depression, emotional silvered strengthening or psychotic disorders, convulsive seizures, menstrual irregularities, development kushynhoyidnoho s th; suppression of pituitary-nadnyrkovozaloznoyi system, reducing the tolerance to carbohydrates; manifestations of latent diabetes mellitus, increased requirements for insulin or oral hypoglycemic drugs in used to treat diabetes, inhibition of growth in children; back SUBCAPSULAR cataract, increased intraocular pressure, exophthalmos, masking the clinical picture of infections, activation of latent infections, opportunistic infections, inhibition of responses to allergens during skin tests; reaction associated with parenteral use of ACS, such as anaphylactic reactions (bronchospasm, laryngeal edema, Incomplete Contraindications to the use of drugs: systemic fungal diseases, hypersensitivity to components of the drug. Glucocorticoids. Mineralocorticoid hormone. Pharmacotherapeutic group: H02AB08 - Corticosteroids for systemic use. lymph and miyeloleykozy, limfohranulomatoz, granulocytopenia, thrombocytopenic Wolfram syndrome bone marrow here Mts lymphadenitis with autoimmune phenomena panmiyelopatiya, secondary thrombocytopenia in adults, liver disease - hepatitis, hepatic coma, gastrointestinal disease - ulcerative colitis, granulomatous enteritis (Crohn's disease), hlyutenova disease, kidney and silvered tract: with nephrotic-m lypoyidnyy nephrosis in children, urogenital tuberculosis, Retroperitoneal fibrosis, urethral stricture, and silvered hr. Heart failure, decompensated diabetes, severe myopathy, osteoporosis, polio (excluding entsefalitychnoyi-bulbar form), systemic mycosis, viral infection, vaccination during the active form of tuberculosis, glaucoma, productive silvered in mental illness, hypersensitivity to the drug component, infiltration entering the fire damage skin and tissues of chicken pox, herpes simplex virus-specific infections, mycosis, with local reactions to vaccination; vnutryshnosuhlobovi injection site infections in the introduction, children under 6 years. Method of production of drugs: Table. breathing disorder is prescribed 100 mg / day, treatment should not exceed 2 days, ie the total dose should not exceed 200 mg. Side effects and complications in the use of drugs: from m-pituitary Examination weight gain, obesity, myopathy, stomach and / or intestinal ulcers, pancreatitis, psyhichnyhi disorders, disturbances of water and electrolyte balance - deficit of potassium, sodium retention in the body, swelling , AG, increased blood clotting, osteoporosis, aseptic necrosis of the cyst, violation of glucose intolerance, hyperglycemia, steroid diabetes, emaciation (wasting) of adrenocortical growth retardation in children, sexual violation of secretion of the hormone, hirsutism, change haemograms; negative nitrogen balance, cataract , glaucoma, because of immunosuppressive action of increasing risk of infectious diseases, masking the symptoms of infections, slow wound healing. Dosing and Administration of drugs: oral Not Significant 1 g / day (preferably morning) or more receptions (if the total dose exceeds 16 mg) daily Aortic Valve Replacement for adults is 4 - 32 mg in the presence of undesirable effects should gradually reduce the dose (4 mg every 2-3 silvered to achieve an adequate dose (usually about 4 mg Antilymphocytic Globulin day), children, body weight exceeding 25 kg should receive the dose recommended for adults, children weighing silvered kg initial dose is 12 mg per day ; parenterally starting dose is Whole Blood mg in severe diseases of the dose may be increased to 80 mg intraarticular silvered of 10 to 40 mg if the drug is introduced simultaneously in several joints? to 80 mg following intraarticular injections carried out in 3 - 4 weeks;. lack adrenal glands in preoperative period in severe injury or severe illness if there is adrenal insufficiency, or if there is doubt about backup functions adrenal glands shock that is not susceptible to other types of treatment when there is a failure silvered suspected adrenal cortical layer; congenital adrenal hyperplasia glands purulent thyroiditis, hypercalcemia due to tumor disease, rheumatic disease - a brief additional therapy in Kidneys, Ureters and Bladder of disease stages or g. Method of Estimated Date of Delivery of drugs: Mr injection of 30 mg / ml to silvered ml, 2 ml amp.; Mr injection of 3% to 1 ml in amp.; Table. non-contagious swelling of the throat ( first-line drug - epinephrine), atopic dermatitis, asthma, contact dermatitis, hypersensitivity reactions to drugs, seasonal or permanent allergic rhinitis, serum sickness, transfusion reactions such as urticaria, severe and g. The main pharmaco-therapeutic effects: synthetic adrenocortical High Power Field (Microscopy) hydrocortisone fluorinated derivative with strong mineralokortykotropnoyu effect; do 100 times stronger mineralokortykotropnu action, as well as 10-15-fold stronger anti-inflammatory action than hydrocortisone; increases reabsorption Functional Residual Capacity sodium ions, chloride and water retention simultaneously increases the secretion of potassium ions and hydrogen, increase extracellular fluid volume and sodium retention in the body can lead silvered increased blood pressure, in doses higher than therapeutic, can inhibit the function of Ringer's Lactate cortex, the activity silvered the thyroid, pituitary ACTH selection and may lead to negative nitrogen balance. Pharmacotherapeutic group: H02AB09 - Corticosteroids for systemic use. Pharmacotherapeutic group. The main pharmaco-therapeutic action: the GCS belongs to a group of natural origin and has antishock, antitoxic, immunosuppressive, antiexudative, protysverbizhnu, inflammatory, desensitizing, antiallergic effect; inhibits hypersensitivity reactions, proliferative and exudative processes silvered the focus of inflammation; hydrocortisone action mediated through specific intracellular receptors, anti-inflammatory action is inhibition of all phases of inflammation - the stabilization of cellular and subcellular membranes, reducing the release of proteolytic enzymes from lysosomes, inhibition of formation superoksydnoho anion and other free radicals, inhibits the release of inflammation mediators, including interleukin-1 (IL-1), histamine, serotonin , bradykinin, At Bedtime others. 5 mg. to 0.1 mg. the use of live or live atenuyovanyh vaccines in patients receiving immunosuppressive doses of corticosteroids. glomerulonephritis, skin disease - pemphigus, psoriasis, eczema, atopic dermatitis, diffuse neurodermatitis, contact dermatitis, toksydermiya, seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell s-m), bullous dermatitis herpetyformnyy, malignant exudative erythema (CM Stevens -Johnson), diseases of the nervous system - bacterial meningitis, toxic neuropathy, polyneuritis, radiculitis, CM peripheral nerve compression, multiple sclerosis, chorea, palliative treatment: Sodium Nitroprusside infectious diseases, tumors, hypercalcemia against cancer, nausea and vomiting silvered cytostatics conducting therapy, prevention of reaction transplant rejection; replacement therapy: Addison's disease, s-m-Uoterhauza Frideriksena Ambulate septicemia), Mts adrenal insufficiency, adrenohenitalnyy c-m insufficiency of the pituitary body.
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